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Updated: Jul 27, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Selective activation of TGFβ signaling by

Shegan Gao1,2, Ke Liu2, Yelin Jiao1

  • 1State Key Laboratory of Esophageal Cancer Prevention & Treatment, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology Luoyang 471003, Henan, China.

American Journal of Cancer Research
|June 9, 2023
PubMed
Summary

Porphyromonas gingivalis infection activates TGFβ/Smad signaling in Esophageal Squamous Cell Carcinoma (ESCC) via GARP, promoting tumor growth and poor prognosis. Targeting this pathway offers a potential ESCC treatment strategy.

Keywords:
GARPPorphyromonas gingivalisTGFβesophageal cancer

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