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A comparative

Shu-Qi Ren1, Yuan Ma2, Li-Lan Fu1

  • 1GuangDong Medical Products Administration (GDMPA) Key Laboratory for Quality Control and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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|June 9, 2023
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Summary
This summary is machine-generated.

A new probe, 18F-PD-L1P, shows superior sensitivity for detecting Staphylococcus aureus osteomyelitis compared to 18F-FDG. This nuclear imaging tool offers earlier and more accurate diagnosis for infection-induced bone disease.

Keywords:
18F-FDGPD-L1PET imagingimplant-associated Staphylococcus aureus osteomyelitisosteomyelitis

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Area of Science:

  • Nuclear Medicine
  • Infectious Diseases
  • Orthopedics
  • Immunology

Background:

  • Osteomyelitis diagnosis is critical for treatment success, with increased PD-L1 expression often indicating infection.
  • Nuclear imaging, particularly PET, offers non-invasive, whole-body assessment of PD-L1 expression.
  • Implant-associated Staphylococcus aureus osteomyelitis (IAOM) presents diagnostic challenges.

Purpose of the Study:

  • To compare the efficacy of 18F-FDG and a novel 18F-labeled PD-L1-binding peptide probe (18F-PD-L1P) in PET imaging of IAOM.
  • To evaluate the sensitivity and accuracy of 18F-PD-L1P for early detection of S. aureus osteomyelitis.

Main Methods:

  • Synthesis of an anti-PD-L1 probe (18F-PD-L1P).
  • Comparison of 18F-FDG and 18F-PD-L1P in PET imaging of IAOM in rat tibias at 7 and 21 days post-infection.
  • Quantification of probe uptake using %ID/g ratios and correlation with PD-L1 immunohistochemistry (IHC) findings.

Main Results:

  • 18F-PD-L1P demonstrated significantly higher %ID/g ratios than 18F-FDG at both 7 and 21 days post-infection (P=0.001 and P=0.028, respectively).
  • The uptake intensity of 18F-PD-L1P correlated with pathological changes observed in osteomyelitic bones.
  • 18F-PD-L1P provided earlier and more sensitive detection of S. aureus osteomyelitis compared to 18F-FDG.

Conclusions:

  • The 18F-PD-L1P probe is a promising radiotracer for the early and accurate diagnosis of S. aureus osteomyelitis.
  • This novel probe enhances diagnostic capabilities for infection-induced bone diseases.