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Updated: Jul 27, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
Published on: December 29, 2021
A focus on how latent "codons" are unravelled in synthetic copolymers
Christopher Barner-Kowollik1,2, Bryan T Tuten1
1School of Chemistry and Physics, Centre for Materials Science, Queensland University of Technology (QUT) 2 George Street Brisbane QLD 4000 Australia christopher.barnerkowollik@qut.edu.au bryan.tuten@qut.edu.au.
Abstract:
We contextualize and highlight an innovative methodology for copolymer analysis introduced by Hibi et al. in Chemical Science (Y. Hibi, S. Uesaka and M. Naito, Chem. Sci., 2023, https://doi.org/10.1039/D2SC06974A). The authors introduce an advanced mass spectrometric method driven by a learning algorithm, termed 'reference-free quantitative mass spectrometry' (RQMS) for decoding sequences of copolymers in real time, including as a function of reaction progress. We highlight potential future implications and applications of the RQMS technique, as well as look forward to where else RQMS could be utilized within the soft matter materials space.
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