Related Experiment Video
Updated: Jul 27, 2025

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
Distal
Manickam Bakthadoss1, Tadiparthi Thirupathi Reddy1
1Department of Chemistry, Pondicherry University Pondicherry 605014 India bhakthadoss@yahoo.com.
Abstract:
Development of a novel strategy for the palladium-catalyzed selective meta-C-H activation of α-substituted cinnamates and their heterocyclic analogues with various alkenes using nitrile as a directing group (DG) has been described. Importantly, we introduced naphthoquinone, benzoquinones, maleimides and sulfolene as coupling partners in the meta-C-H activation reaction for the first time. Notably, allylation, acetoxylation and cyanation were also achieved through distal meta-C-H functionalization. This novel protocol also includes the coupling of various olefin-tethered bioactive molecules with high selectivity.
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