Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

7.1K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
7.1K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K
Structure of Cadherins01:25

Structure of Cadherins

3.4K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.4K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.4K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.4K
Amyloid Fibrils03:03

Amyloid Fibrils

9.6K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.6K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

9.0K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitrosylium Hexafluorouranate (NOUF<sub>6</sub>) and Its Derivatives.

Inorganic chemistry·2026
Same author

Mechanism of Action and Membrane Interactions of Antibacterial Quaternized Triazolium Peptoids.

Journal of medicinal chemistry·2025
Same author

Transketolase catalytic reaction pathway. Study of thiamine diphosphate activation and complete catalytic cycle.

Methods in enzymology·2025
Same author

Synthesis of Nitrogen Oxyfluorides at Low Temperature Monitored by Barometry and Infrared Spectroscopy.

ACS omega·2025
Same author

Interactions of insulin aspart hexamer and excipients with plasticized polyvinyl chloride surfaces: A comprehensive investigation combining molecular simulations and experiments.

International journal of biological macromolecules·2025
Same author

Solid-Phase Synthesis of Peptoid Oligomers Containing Crowded <i>tert</i>-Butyl Side Chains.

The Journal of organic chemistry·2025
Same journal

Bi-modified Ni<sub>3</sub>S<sub>2</sub> promotes selective nitrite-to-hydroxylamine reduction for cyclohexanone oxime synthesis.

Chemical communications (Cambridge, England)·2026
Same journal

Cyclable manganese inventory as a mechanistic descriptor for electrolyte design in rechargeable aqueous Zn-MnO<sub>2</sub> batteries.

Chemical communications (Cambridge, England)·2026
Same journal

Cobalt-iron layered double hydroxides with ligand modification for boosting glycerol electrooxidation-assisted hydrogen production.

Chemical communications (Cambridge, England)·2026
Same journal

Beyond the vacuum: modeling the solid-liquid interface for gas-involving electrocatalysis.

Chemical communications (Cambridge, England)·2026
Same journal

Alkaline-earth carbonate-supported Ru for quinoline hydrogenation: enhanced H<sub>2</sub> activation <i>via</i> electronic metal-support interaction.

Chemical communications (Cambridge, England)·2026
Same journal

Mitigating ionic conductivity limitations <i>in operando</i> electrochemical X-ray photoelectron spectroscopy.

Chemical communications (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.1K

Cage-like structures based on constrained cyclic arylopeptoids.

Ayman Akhdar1, Lionel Nauton1, Laurent Jouffret1

  • 1Université Clermont Auvergne, CNRS, ICCF, Clermont-Ferrand F-63000, France. sophie.faure@uca.fr.

Chemical Communications (Cambridge, England)
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

Researchers synthesized novel cupola-like and tube-like macrocycles using copper-catalyzed azide-alkyne cycloaddition. The resulting bis-triazolium compounds exhibit defined structures and show potential for oxoanion recognition.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

7.9K

Related Experiment Videos

Last Updated: Jul 27, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.3K
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

7.9K

Area of Science:

  • Organic Chemistry
  • Supramolecular Chemistry

Background:

  • Macrocyclic compounds offer unique structural scaffolds.
  • Arylopeptoids provide versatile building blocks for complex architectures.

Purpose of the Study:

  • To synthesize cupola-like and tube-like macrocycles from arylopeptoid precursors.
  • To investigate the structural properties and potential applications of the synthesized compounds.

Main Methods:

  • Copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
  • Utilized a partially flexible bis(azide) and a copper(I)-N-heterocyclic carbene catalyst.
  • Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation.

Main Results:

  • Successfully accessed ortho- and meta-arylopeptoid macrocycles with cupola-like or tube-like structures.
  • NMR studies confirmed a well-defined bicyclic bis-triazolium structure in various solvents.
  • Preliminary investigations suggest potential for selective oxoanion recognition.

Conclusions:

  • The study demonstrates a viable route to novel arylopeptoid macrocycles.
  • The synthesized bis-triazolium compounds possess predictable structural features.
  • These macrocycles show promise as host molecules for anion binding.