Failure of naloxone to reduce self-injurious behavior in two developmentally disabled females

Three doses of Naloxone (0.1, 0.2 and 0.4 mg.) were compared to treatment with saline in a double-blind crossover design. Neither of the two female subjects altered their rate of self-injurious behavior as a result of treatment. The present results suggest that naloxone does not reduce self-injurious behavior in all individuals.