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Optofluidic lasers and their applications in biochemical sensing
Hongrui Zhang1, Ya-Nan Zhang1,2,3, Like Li1
1College of Information Science and Engineering, Northeastern University, Shenyang, 110819, China. zhangyanan@ise.neu.edu.cn.
Lab on a Chip
|June 9, 2023
Summary
Optofluidic lasers (OFLs) integrate microfluidics and laser technology for highly sensitive biochemical analysis. OFL-based sensors detect biochemical changes through laser output variations, enabling precise measurements.
Area of Science:
- Optofluidics
- Biochemical Sensing
- Laser Technology
Background:
- Optofluidic laser (OFL) technology merges microfluidics and laser technology.
- It offers unique advantages for sensing applications, particularly in highly-sensitive intracavity biochemical analysis.
- OFL-based sensors achieve high detection sensitivity by correlating changes in laser output characteristics with biochemical parameter variations.
Purpose of the Study:
- To provide a comprehensive overview of optofluidic lasers (OFLs).
- To focus on the construction, design, and applications of OFL-based biochemical sensors.
- To discuss current research progress, challenges, and future directions in OFL biochemical sensing.
Main Methods:
- Systematic description of the three core elements of an OFL: optical microcavity, gain medium, and pump source.
- Explanation of the fundamental principles and characterization techniques for OFLs in biochemical sensing.
- Summary and analysis of OFL-based biochemical sensors combined with various assay techniques.
Main Results:
- Detailed review of OFL constructions and their integration into biochemical sensor designs.
- Analysis of research progress in OFL applications for detecting biological macromolecules, cells, and tissues.
- Identification of key advancements in OFL technology for sensitive biochemical detection.
Conclusions:
- OFL technology is a promising platform for advanced biochemical sensing.
- Current research highlights the potential of OFLs in analyzing biological samples at multiple levels.
- Future development should address existing challenges to further enhance OFL applications in biochemical analysis.
