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Value of systemic inflammation-response index in predicting contrast-induced nephropathy in patients with

Cennet Yildiz1, Yasin Yuksel2, Suleyman Cagan Efe3

  • 1Cardiology Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Acta Cardiologica
|June 9, 2023
PubMed

Insights

Systemic inflammatory-response index (SIRI) effectively predicts contrast induced nephropathy (CIN) in patients undergoing percutaneous intervention. SIRI demonstrated higher diagnostic power than neutrophil/lymphocyte ratio (NLR) and monocyte/lymphocyte ratio (MLR) for identifying high-risk patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Inflammation Markers

Background:

  • Contrast induced nephropathy (CIN) is a significant complication of procedures using contrast media.
  • Identifying patients at high risk for CIN is crucial for preventative strategies.

Purpose of the Study:

  • To evaluate the predictive value of the systemic inflammatory-response index (SIRI) for the development of CIN.
  • To compare the diagnostic power of SIRI against other inflammatory markers like NLR and MLR.

Main Methods:

  • A cohort of 676 patients with ST-elevation myocardial infarction undergoing primary percutaneous intervention were analyzed.
  • Patients were categorized into groups with and without CIN.
  • Clinical and biochemical data, including SIRI, neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR), were collected and analyzed.

Main Results:

  • Patients who developed CIN were older and had higher levels of creatinine, inflammatory markers (NLR, MLR, SIRI), and hyperlipidaemia.
  • SIRI showed the highest area under the curve (AUC) for predicting CIN, outperforming NLR and MLR.
  • Multivariate analysis identified SIRI and NLR as independent predictors of CIN, with SIRI having a higher odds ratio.

Conclusions:

  • SIRI is a potent predictor of CIN in patients undergoing percutaneous intervention.
  • SIRI offers superior diagnostic power compared to NLR and MLR for identifying patients at risk of CIN.
  • SIRI is a practical tool for clinicians to assess CIN risk.
Abstract

Keywords:
ST elevationSystemic inflammation-response indexcontrastmyocardial infarctionnephropathyoutcome

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