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Segmentation Errors and Off-Center Artifacts in SS-OCT: Insight from a Population-Based Imaging Study.

Cong Li1, Yixiong Yuan1, Xiangbin Kong2

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Current Eye Research
|June 9, 2023
PubMed
Summary

Nearly one-fifth of eyes in a population study showed artifacts in swept-source optical coherence tomography (SS-OCT) imaging. Increasing age and refractive error were associated with artifact presence, impacting clinical interpretation.

Keywords:
Swept-source optical coherence tomographychoroidal thicknessoptic nerve headpopulation-based studyretinal nerve fiber layer thickness

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Artifacts in optical coherence tomography (OCT) imaging can affect diagnostic accuracy.
  • Swept-source OCT (SS-OCT) offers deeper penetration and faster acquisition but may introduce specific artifacts.
  • Understanding artifact prevalence and associated factors is crucial for reliable interpretation of SS-OCT data.

Purpose of the Study:

  • To determine the frequency of artifacts in SS-OCT imaging of the optic nerve head and peripapillary region.
  • To identify clinical factors associated with the presence of these artifacts.
  • To inform clinical practice regarding the interpretation of SS-OCT scans.

Main Methods:

  • A population-based cross-sectional study involving individuals aged 35 years and older.
  • Random cluster sampling was used for participant recruitment in Guangzhou, China.
  • SS-OCT imaging was performed on a subset of participants, with artifacts in the peripapillary choroidal layer and retinal nerve fiber layer (RNFL) graded and analyzed using logistic regression.

Main Results:

  • 18.3% of peripapillary RNFL (pRNFL) measurements and 13.6% of peripapillary choroidal thickness (pCT) measurements exhibited artifacts.
  • Posterior segmentation error and off-center artifacts were the most common types.
  • Artifact presence was significantly associated with older age and refractive error for both pRNFL and pCT measurements.

Conclusions:

  • Artifacts are present in a notable proportion of SS-OCT scans in a general population.
  • Age is a significant risk factor for artifact development in SS-OCT imaging.
  • These findings highlight the importance of considering artifactual changes when interpreting SS-OCT results in clinical settings.