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Updated: Jul 27, 2025
Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Organocatalytic (1+4)-Annulations of MBH Adducts with Electron-Deficient Systems
1Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Guangming Advanced Research Institute, College of Science, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong, 518055, China.
Abstract:
Benefited from the rapid development of MBH reaction, the reaction of MBH adducts have been established as the most synthetically useful transformations. However, compared with the well-established allylic alkylations and (3+2)-annulations, the (1+4)-annulations of MBH adducts have not developed rapidly until recently. As a helpful complement to the (3+2)-annulations of MBH adducts, the (1+4)-annulations of MBH adducts opens a robust access to structurally diverse five-membered carbo- and heterocycles. This paper summarizes recent advances in organocatalytic (1+4)-annulations using MBH adducts as 1 C-synthons for the construction of functionalized five-membered carbo- and heterocycles.
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