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Design, Fabrication, and Administration of the Hand Active Sensation Test HASTe
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H

Jun Wang1, Nan Zhang2, Hong-Zheng Liu2

  • 1Department of Orthopaedics, The Graduate School, Tianjin University, Tianjin, China.

Journal of Molecular Neuroscience : MN
|June 9, 2023
PubMed
Summary

Hydrogen sulfide (H2S) therapy alleviates neuropathic pain by activating the Nrf2 pathway. This treatment reversed pain behaviors and normalized cellular changes in a mouse model of chronic constriction injury.

Keywords:
H2SNeuropathic painNrf2Oxidative stressvGlut2

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Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Background:

  • Neuropathic pain arises from nervous system damage, causing heightened sensitivity.
  • Hydrogen sulfide (H2S) shows therapeutic potential for neuropathic pain, but mechanisms are unclear.

Purpose of the Study:

  • To investigate if H2S therapy can treat neuropathic pain in a mouse model.
  • To elucidate the underlying molecular mechanisms of H2S's therapeutic effects.

Main Methods:

  • Established a chronic constriction injury (CCI) mouse model.
  • Administered intrathecal NaHS (H2S donor) for treatment.
  • Assessed pain behaviors (thermal and mechanical thresholds).
  • Conducted molecular analyses: immunofluorescence, ELISA, electrophysiology, mtDNA/ATP quantification, Western blot.

Main Results:

  • CCI mice showed reduced pain thresholds, increased inflammatory markers (IL-1β, TNF-α), and altered neuronal activity.
  • H2S treatment reversed these CCI-induced changes.
  • H2S upregulated Nrf2 signaling, H3K4 methylation, and vGlut2 expression in specific neurons.
  • Inhibiting Nrf2 with ML385 abolished H2S's protective effects.

Conclusions:

  • H2S therapy effectively mitigates neuropathic pain in a CCI mouse model.
  • The protective mechanism involves activating the Nrf2 signaling pathway within vGlut2-positive neurons.