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Virus infection participates in the occurrence and development of human diseases through monoamine oxidase

Yujie Sun1, Wen Liu1, Bing Luo1

  • 1Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, China.

Reviews in Medical Virology
|June 9, 2023
PubMed

Insights

This review explores how viral infections impact human diseases via monoamine oxidase (MAO). It examines MAO inhibitors

Area of Science:

  • Biochemistry
  • Virology
  • Neuroscience

Background:

  • Monoamine oxidase (MAO) is a crucial mitochondrial enzyme regulating neurotransmitter levels.
  • MAO dysfunction is linked to neurological disorders, psychiatric diseases, and cancers.
  • The role of MAO in human viral infections remains largely unexplored.

Purpose of the Study:

  • To review current research on the involvement of MAO in viral pathogenesis.
  • To explore the impact of MAO on the development of viral diseases.
  • To investigate the effects of MAO inhibitors on viral infections.

Main Methods:

  • Comprehensive literature review of studies on MAO and viral infections.
  • Analysis of research linking specific viruses (HCV, DENV, SARS-CoV-2, HIV, JEV, EBV, HPV) to MAO.
  • Examination of data on MAO inhibitors (phenelzine, clorgyline, selegiline, M-30, isatin) in viral contexts.

Main Results:

  • Viral infections can influence MAO activity and expression.
  • MAO may play a role in the pathogenesis of various viral diseases.
  • MAO inhibitors show potential therapeutic effects against certain viral infections.

Conclusions:

  • MAO is implicated in the pathogenesis of diverse viral infections.
  • Understanding MAO's role offers new diagnostic and therapeutic strategies for viral diseases.
  • Further research into MAO-targeted therapies for viral infections is warranted.
Keywords:
diseasemonoamine oxidasemonoamine oxidase inhibitorsneurotransmittersvirus

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