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Related Experiment Videos

[Electrocardiographic and hemodynamic changes during systemic hyperthermia (42 degrees C)].

M Yokoyama, J Wada, H Nakajima

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |April 1, 1986
    PubMed
    Summary

    Systemic hyperthermia (42°C) significantly alters electrocardiogram (ECG) readings, causing ST-segment depression and bundle branch blocks. These transient cardiac changes resolve upon returning to normal body temperature.

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    Area of Science:

    • Cardiology
    • Physiology

    Context:

    • Systemic hyperthermia is a medical condition involving elevated body temperature.
    • Understanding the cardiac effects of hyperthermia is crucial for patient management.

    Purpose:

    • To investigate the electrocardiographic (ECG) changes associated with induced systemic hyperthermia at 42°C.
    • To document the prevalence and nature of cardiac arrhythmias and conduction abnormalities during fever.

    Summary:

    • Elevated body temperature to 42°C induced significant ECG abnormalities in 56% of patients, including ST-segment depression and T-wave changes.
    • Right bundle branch block (29%), supraventricular tachycardia (26%), and left axis deviation (15%) were observed.
    • These transient ECG changes resolved upon normalization of body temperature and were reproducible during subsequent hyperthermic episodes.

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    Impact:

    • The study highlights the significant, yet reversible, impact of hyperthermia on cardiac electrical activity.
    • Findings are essential for clinicians interpreting ECGs in febrile patients.
    • Provides insights into cardiovascular adaptation during fever, noting a 1.7-fold increase in pulse rate and up to 2.4-fold increase in cardiac output.