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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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Updated: Jul 27, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Sequence variants affecting voice pitch in humans.

Rosa S Gisladottir1,2, Agnar Helgason1,3, Bjarni V Halldorsson1,4

  • 1deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

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|June 9, 2023
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Summary
This summary is machine-generated.

Scientists discovered genetic links to voice pitch and vowel acoustics in 12,901 Icelanders. Common variants in the ABCC9 gene influence voice pitch, offering insights into the genetics of human speech.

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Area of Science:

  • Genetics
  • Bioacoustics
  • Human Evolution

Background:

  • The genetic underpinnings of the human vocal system and individual voice/speech variations remain largely unexplored.
  • Understanding the genetic basis of vocal traits is crucial for fields ranging from linguistics to medicine.

Purpose of the Study:

  • To investigate the genetic influences on voice pitch and vowel acoustics.
  • To identify specific genetic variants associated with variations in human voice characteristics.
  • To explore the correlation between vocal traits and other biological and cognitive factors.

Main Methods:

  • Genome sequencing data from 12,901 Icelandic individuals was analyzed.
  • Voice and vowel acoustics were measured from speech recordings.
  • Statistical analyses were performed to correlate genetic data with acoustic measurements and other traits.

Main Results:

  • Voice pitch and vowel acoustics demonstrate a heritable component.
  • Common variants in the ABCC9 gene were found to be associated with voice pitch.
  • These ABCC9 variants also showed associations with adrenal gene expression and cardiovascular traits.

Conclusions:

  • Vocal acoustics, including voice pitch and vowel characteristics, are influenced by genetic factors.
  • The identification of ABCC9 variants provides a genetic link to voice pitch.
  • This research represents a significant step towards understanding the genetic basis and evolutionary aspects of the human vocal system.