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Theranostic Surrogacy of [

Su Bin Kim1,2, Min Seob Lee2, In Ho Song2

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This study developed a novel method for precise dosimetry in differentiated thyroid cancer (DTC) using iodine isotopes. The approach improves personalized medicine by accurately estimating radiation dose for targeted radiopharmaceutical therapy.

Keywords:
biodistributiondifferentiated thyroid cancerinternal radiation dosimetrysimplified dosimetrysurrogatetheranostics

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Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Therapy
  • Medical Physics

Background:

  • Precise dosimetry is crucial for novel radiopharmaceuticals and improving conventional therapies.
  • Existing radioiodine theranostic applications for differentiated thyroid cancer (DTC) lack personalized dosing strategies.
  • There's a need for improved dosimetry extrapolation for companion diagnostic radiopharmaceuticals.

Purpose of the Study:

  • To investigate the theranostic surrogacy of companion radiopharmaceuticals in DTC xenograft mouse models.
  • To develop and validate a novel, simplified approach for voxel-level dosimetry.
  • To determine optimal scan time points for pretherapeutic dosimetry using surrogate radiotracers.

Main Methods:

  • Generation of DTC xenograft mouse models with validated sodium iodine symporter (NIS) protein uptake.
  • Utilized single photon emission computed tomography (SPECT) imaging and Monte Carlo simulations for dose distribution analysis.
  • Employed [123I]NaI SPECT scans and 131I ion source simulation to estimate absorbed dose, incorporating subject-specific tissue data.

Main Results:

  • Peak tumor concentration of [123I]NaI was 96.49 ± 11.66% ID/g at 2.91 ± 0.42 h post-injection.
  • Estimated absorbed dose for 131I therapy was 0.0344 ± 0.0088 Gy/MBq.
  • The proposed simplified dosimetry method using Tmax and 26 h scan points achieved accurate absorbed dose estimates within [-22.96, 2.21%].

Conclusions:

  • The study provides an experimental foundation for evaluating radiation dose distribution in DTC.
  • The novel dosimetry approach simplifies voxel-level calculations and identifies optimal scan timings for pretherapeutic assessment.
  • This work is expected to enhance the clinical dosimetry process for radiopharmaceutical therapies.