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Related Experiment Video

Updated: Jul 27, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Lymphomas in pregnancy.

Maria Cristina Pirosa1,2, Fedro Alessandro Peccatori3

  • 1Clinic of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Hematological Oncology
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

Managing lymphoma during pregnancy requires a multidisciplinary approach. Treatment for Hodgkin lymphoma and aggressive non-Hodgkin lymphomas (NHL) depends on gestational age, with specific chemotherapy regimens considered safe after 13 weeks.

Keywords:
Hodgkin lymphomafetal toxicitynon Hodgkin lymphomapregnancy

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Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Hematology

Background:

  • Lymphoma diagnosis during pregnancy presents unique challenges.
  • Management necessitates a collaborative team including obstetricians, hematologists, and neonatologists.

Purpose of the Study:

  • To outline management strategies for lymphoma in pregnant patients.
  • To review treatment safety based on lymphoma subtype and gestational age.

Main Methods:

  • Literature review of lymphoma treatment protocols in pregnancy.
  • Analysis of chemotherapy safety data concerning gestational age and fetal outcomes.

Main Results:

  • Hodgkin lymphoma treatment with ABVD is safe after 13 weeks gestation.
  • For aggressive non-Hodgkin lymphomas (NHL), R-CHOP is safe after 13 weeks; termination may be considered earlier.
  • Indolent NHLs may be managed with watchful waiting.

Conclusions:

  • Treatment decisions for lymphoma in pregnancy must be individualized based on histotype and gestational age.
  • Limited data exist on novel anti-lymphoma drugs' fetotoxicity, necessitating mandatory data collection for future guidance.