Optimization of isocenter position for multiple brain metastases single-isocenter stereotactic radiosurgery to...

This paper studied a novel calculation framework that can determine the optimal value isocenter position of single isocenter SRS treatment plan for multiple brain metastases, in order to minimize the dosimetric variations caused by rotational uncertainty.

21 patients with 2-4 GTVswho received SRS treatment for multiple brain metastases in our institution were selected for the retrospective study. The PTVwas obtained by expanding GTV 1 mm isotropic margin. We studied a stochastic optimization framework, which determined the optimal value isocenter location by maximizing the average target dose coverageC_target,meanwith a rotation error of no more than 1°. We evaluated the performance of the optimal isocenter by comparing theC_target,meanand average dice similarity coefficient (DSC)with the optimal value and the center of mass (CM) respectively as the treatment isocenter. The extra PTV margin to achieve 100% target dose coverage was calculated by our framework.

Compared to the CM method, the optimal value isocenter method increased the averageC_target,meanof all targets from 97.0% to 97.7%and the average DSC from 0.794to 0.799. Throughout all the cases, the average extra PTV margin to obtain full target dose coverage was 0.7 mmwhen using the optimal value isocenter as the treatment isocenter.

We studied a novel computational framework using stochastic optimization to determine the optimal isocenter position of SRS treatment plan for multiple brain metastases. At the same time, our framework gave the extra PTV margin to obtain full target dose coverage.