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When GETomics meets aging and exercise in COPD.

D Pellegrino1, S Casas-Recasens2, R Faner3

  • 1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy; Respiratory and Critical Care Unit, Policlinico Umberto I Hospital of Rome, Italy.

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|June 9, 2023
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Summary
This summary is machine-generated.

The GETomics framework highlights how gene-environment interactions throughout life, including epigenetic changes, shape health and disease. This perspective redefines chronic obstructive pulmonary disease (COPD) beyond traditional views, considering diverse risk factors and individual trajectories.

Keywords:
BronchitisDevelopmentEmphysemaSmokingSpirometry

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Area of Science:

  • Genetics and Environmental Health
  • Systems Biology
  • Pulmonary Medicine

Background:

  • The GETomics paradigm integrates gene-environment (GxE) interactions over an individual's lifetime (T).
  • This approach considers cumulative GxE exposures, epigenetic modifications, and immune memory.
  • It challenges traditional, single-factor views of disease etiology.

Purpose of the Study:

  • To re-evaluate the pathogenesis of chronic obstructive pulmonary disease (COPD) through the lens of GETomics.
  • To explore how GETomics can offer new insights into COPD, exercise limitation, and aging.
  • To broaden the understanding of COPD beyond its traditional association with smoking in older men.

Main Methods:

  • Conceptual framework application: GETomics applied to COPD.
  • Literature review and synthesis of existing research on COPD pathogenesis.
  • Analysis of GxE interactions, epigenetics, and immune memory in disease development.

Main Results:

  • COPD is understood as a multifactorial disease influenced by lifetime GxE interactions, not solely smoking.
  • Recognizes COPD in diverse populations (females, younger individuals) and varied lung function decline patterns.
  • Highlights the role of cumulative exposures and biological memory in COPD.

Conclusions:

  • A GETomics approach provides a more comprehensive understanding of COPD etiology and progression.
  • This framework may elucidate the complex relationships between COPD, exercise intolerance, and the aging process.
  • Future research should incorporate lifetime GxE interactions to unravel COPD's complexities.