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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Effect of Aerobic/Strength Training on RANKL Gene DNA Methylation Levels.

Ameni Chelly1,2, Amal Bouzid1,3, Fadoua Neifar1

  • 1Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, University of Sfax, Sfax,Tunisia.

Journal of Physical Activity & Health
|June 9, 2023
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Summary

Physical activity significantly increases DNA methylation in the RANKL promoter region, a key factor in bone remodeling. Exercise may reduce osteoporosis risk by altering these epigenetic changes.

Keywords:
aerobic trainingepigeneticsosteoporosisphysical exercise

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Area of Science:

  • Epigenetics
  • Bone Biology
  • Exercise Physiology

Background:

  • The Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL) gene is crucial for bone remodeling.
  • Hypomethylation of the RANKL promoter may contribute to osteoporosis.
  • Physical activity's impact on RANKL DNA methylation is not fully understood.

Purpose of the Study:

  • To investigate how physical activity influences DNA methylation in the RANKL promoter region.
  • To assess the effects of aerobic and strength training on RANKL DNA methylation in adults.

Main Methods:

  • Recruited 104 adults for observational and interventional phases.
  • Intervention included 12 weeks of aerobic and strength training.
  • Collected blood samples for quantitative methylation-specific PCR analysis and used the International Physical Activity Questionnaire.

Main Results:

  • Active adults showed a significant 6.68-fold increase in RANKL promoter methylation compared to sedentary adults (P = 6 × 10-10).
  • Both trained and untrained groups exhibited increased RANKL promoter methylation post-intervention.
  • Trained individuals showed significant improvements in cardiovascular health and body composition.

Conclusions:

  • Epigenetic modifications in the RANKL promoter are linked to osteoporosis.
  • Aerobic and strength training may enhance bone health and reduce osteoporosis vulnerability by increasing RANKL DNA methylation.