Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

402
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient specific quality assurance: The final safety net in radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Streamlining Paediatric Palliative Radiotherapy: A Case Study on Reducing Procedural Burden and Avoiding General Anaesthesia Using a Simulation-Free Radiotherapy (SF-RT) Protocol.

Journal of medical radiation sciences·2026
Same author

Digital safeguarding incidents in schools with and without smartphone policies: a cross-sectional study in England.

Child and adolescent mental health·2026
Same author

Eurocentric Bias in Dysmorphology and Medical Genetics Education.

American journal of medical genetics. Part A·2026
Same author

Review of current best practice in radiation oncology for older adults with cancer: Updates from the International Society of Geriatric Oncology (SIOG) Task Force.

Journal of geriatric oncology·2025
Same author

Deep Plane Technique for Male Facelift Surgery.

Facial plastic surgery : FPS·2025

Related Experiment Video

Updated: Jul 27, 2025

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K

Improving plan quality in cervical brachytherapy using a simple knowledge-based prediction tool for OAR dose (D2cm

Emily Flower1, Jonathan Sykes1, Emma Sullivan2

  • 1Sydney West Radiation Oncology Network, Westmead, New South Wales, Australia; School of Physics, University of Sydney, Sydney, Australia.

Brachytherapy
|June 9, 2023
PubMed
Summary

Simplified knowledge-based planning predicts organ-at-risk doses in cervical brachytherapy. This method automates optimization, improving plan quality and reducing toxicity for patients with locally advanced cervical cancer.

Keywords:
Cervical cancerKnowledge-based planningPlan quality

More Related Videos

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K

Related Experiment Videos

Last Updated: Jul 27, 2025

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Oncology

Background:

  • Cervical brachytherapy toxicity correlates with organ-at-risk (OAR) D2cm3 (dose to 2 cm³).
  • Knowledge-based planning (KBP) offers potential for optimizing brachytherapy plans.
  • Investigating simplified KBP for predicting OAR D2cm3 is crucial for reducing toxicity.

Purpose of the Study:

  • To demonstrate the feasibility of simplified KBP for predicting OAR D2cm3 in cervical brachytherapy.
  • To assess KBP's ability to detect suboptimal plans and enhance overall plan quality.
  • To automate the optimization of brachytherapy plans for locally advanced cervical cancer.

Main Methods:

  • Overlap Volume Histogram (OVH) method used to determine 2 cm³ overlap distance between OAR and CTV_HR.
  • Linear models correlated OAR D2cm3 with 2 cm³ overlap distance using two independent patient datasets.
  • Cross-validation compared model performance; doses scaled for consistent CTV_HR D90; predicted D2cm3 used as inverse planning constraint.

Main Results:

  • Mean bladder D2cm3 decreased by 2.9%.
  • Mean rectal D2cm3 decreased by 14.9% (dataset 1) and 6.0% (dataset 2).
  • Mean sigmoid D2cm3 decreased by 10.7% (dataset 1) and 6.1% (dataset 2); bowel D2cm3 decreased by 4.1% (dataset 1).

Conclusions:

  • Simplified KBP effectively predicts D2cm3 for OARs in cervical brachytherapy.
  • This approach automates optimization, leading to improved plan quality.
  • The method shows promise for enhancing treatment outcomes in locally advanced cervical cancer.