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Published on: December 29, 2021
Cannabidiol and pharmacokinetics drug-drug interactions: Pharmacological toolbox
Clémence Lacroix1, Romain Guilhaumou1, Joëlle Micallef1
1Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, University Hospital Federation DHUNE, Service de Pharmacologie Clinique et Pharmacovigilance, 13005 Marseille, France; CEIP-Addictovigilance PACA-Corse, Centre régional de pharmacovigilance Marseille Provence Corse, Laboratoire de Pharmacologie Biologique, 13005 Marseille, France.
Abstract:
Cannabidiol (CBD) is one of the most important components of the Cannabis sativa plant with delta9-tetrahydrocannabinol (THC). CBD is used both for medical and recreational purposes. It can be of pharmaceutical grade (Epidyolex®), and also self-service purchased in pharmacy, CBD shops and on the internet (non-pharmaceutical). CBD is almost as widespread as it is poorly understood from a pharmacological point of view and particularly in terms of drug interactions. Drug-drug interactions could lead to clinical complications, and we here gather data currently available on pharmacokinetics (PK) drug-drug interactions with CBD through a narrative review. This review shows that several PK drug-drug interactions exist with different class of medications and aims to help clinicians to better know about CBD for their practice as this product is increasingly used.
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