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Related Experiment Video

Updated: Jul 27, 2025

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Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum

Shengnan Wang1, Lin Pan2, Rui Wu1

  • 1Department of Neurology, Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Scientific Reports
|June 9, 2023
PubMed
Summary

This study suggests that consuming oily fish and raw vegetables may reduce the risk of aquaporin-4 (AQP4) positive Neuromyelitis Optica Spectrum Disorders (NMOSD). Further research is needed to confirm these dietary links to NMOSD.

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Area of Science:

  • Neuroimmunology
  • Nutritional Epidemiology
  • Genetic Epidemiology

Background:

  • Neuromyelitis Optica Spectrum Disorders (NMOSD) are severe central nervous system inflammatory conditions primarily targeting aquaporin-4 (AQP4) antibodies.
  • Risk factors for NMOSD are not fully understood, but diet and nutrition are potential contributors.
  • Investigating dietary influences is crucial for developing preventative strategies against AQP4-positive NMOSD.

Approach:

  • Employed a two-sample Mendelian randomization (MR) design to assess potential causal links between food intake and AQP4-positive NMOSD.
  • Utilized genetic instruments and self-reported dietary data from a large UK Biobank GWAS (445,779 participants).
  • Analyzed associations using inverse-variance-weighted meta-analysis, weighted-median, and MR-Egger regression, with sensitivity analyses performed.

Key Points:

  • High consumption of oily fish was associated with a reduced risk of AQP4-positive NMOSD.
  • Increased intake of raw vegetables also showed a correlation with decreased AQP4-positive NMOSD risk.
  • Sensitivity analyses confirmed the robustness of findings, with no significant directional pleiotropy detected.

Conclusions:

  • Findings suggest a potential protective role of oily fish and raw vegetables against AQP4-positive NMOSD.
  • These dietary insights could inform future preventative measures for NMOSD.
  • Further investigation is warranted to elucidate the precise causal mechanisms linking specific food intakes to NMOSD development.