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Related Experiment Videos

Multiple-organ failure and sepsis without bacteria. An experimental model.

R J Goris, W K Boekholtz, I P van Bebber

    Archives of Surgery (Chicago, Ill. : 1960)
    |August 1, 1986
    PubMed
    Summary

    Severe inflammation, not just bacterial infection, can cause multiple-organ failure. This study shows that a non-bacterial inflammatory stimulus can trigger sepsis-like conditions, impacting organ function and metabolism.

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    Area of Science:

    • Physiology
    • Immunology
    • Pathology

    Background:

    • Multiple-organ failure (MOF) is often linked to bacterial infections, but blood cultures are not always positive.
    • The precise mechanisms driving MOF in the absence of confirmed bacteremia require further investigation.

    Purpose of the Study:

    • To investigate the impact of a non-bacterial inflammatory stimulus on distant organ function and metabolism.
    • To determine if severe inflammation alone can induce a sepsis-like state and MOF.

    Main Methods:

    • Wistar rats were administered zymosan intraperitoneally to induce inflammation.
    • Physiological parameters (heart rate, oxygen consumption, temperature) were monitored.
    • Survivors underwent post-mortem analysis including blood tests, organ weighing, and microscopy.

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    Main Results:

    • Intraperitoneal zymosan induced a hyperdynamic response with 35% mortality, despite sterile blood cultures.
    • Oxygen consumption decreased, lactate levels rose, and multiple organs failed in surviving rats.
    • Similar results were observed in germ-free rats, indicating a non-bacterial mechanism.

    Conclusions:

    • Severe inflammatory responses, independent of bacterial infection, can precipitate multiple-organ failure.
    • This suggests that inflammation itself is a critical factor in the pathogenesis of sepsis-like conditions.