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Eliana Akemi Komino1, Letícia Pereira Afonso Ramos1, Adriele Vieira de Souza1

  • 1Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre s/n, Bloco 2E, Uberlândia 38400-319, MG, Brazil.

Foods (Basel, Switzerland)
|June 10, 2023
PubMed
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Annona crassiflora Mart. fruit peel extract, rich in polyphenols, demonstrated significant antioxidant effects. It improved the glutathione system in hyperlipidemic mice, suggesting cardioprotective potential.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Cardiovascular Research

Background:

  • Dyslipidemia and oxidative stress are key contributors to cardiovascular disease pathogenesis.
  • Annona crassiflora Mart. (ACM), rich in polyphenols, is traditionally used for inflammation and pain relief.
  • Polyphenols possess potent antioxidant capacities relevant to managing oxidative stress.

Purpose of the Study:

  • To investigate the antioxidant properties of ACM fruit peel extract in the context of hyperlipidemia.
  • To evaluate the cardioprotective effects of ACM's crude ethanol extract (CEAc) and polyphenol-rich fraction (PFAc) on cardiac oxidative stress.

Main Methods:

  • Hyperlipidemic mice were orally administered CEAc or PFAc derived from ACM fruit peel.
  • Cardiac oxidative stress biomarkers were assessed, alongside blood and fecal biochemical data.
Keywords:
araticumcardiovascular diseasedyslipidemiaglutathione defenseoxidative stress

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  • Key antioxidant enzymes and oxidative damage markers were measured.

    • Main Results:

    • CEAc increased glutathione (GSH) and reduced superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase activities.
    • PFAc enhanced total antioxidant capacity and boosted GSH, SOD, and CAT activities, counteracting hyperlipidemia-induced reductions.
    • PFAc administration decreased protein carbonylation and lipid peroxidation, and modulated glutathione reductase and glucose-6-phosphate dehydrogenase activities.

    Conclusions:

    • ACM fruit peel extract, particularly its polyphenol-rich fraction, exhibits significant antioxidant and cardioprotective effects.
    • The extract effectively improves the glutathione system and reduces oxidative damage in hyperlipidemic conditions.
    • ACM demonstrates potential as a natural therapeutic agent for managing cardiovascular diseases linked to oxidative stress.