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Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
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Effect of the Combination of
Ana María García-Muñoz1, Ana I García-Guillén2, Desirée Victoria-Montesinos1
1Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia, 30107 Murcia, Spain.
Foods (Basel, Switzerland)
|June 10, 2023
Summary
Hibiscus sabdariffa (HS) combined with plant extracts shows promise for managing metabolic syndrome. This review found HS improved key health markers, suggesting a beneficial role in cardiovascular health.
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Metabolic Disorders
Background:
- Metabolic syndrome increases cardiovascular disease and type 2 diabetes risk.
- Polyphenol-rich diets, particularly fruits and vegetables, offer cardiovascular protection.
- Hibiscus sabdariffa (HS) and plant extracts are being investigated for metabolic syndrome treatment.
Purpose of the Study:
- To systematically review and meta-analyze the effects of HS combined with other plant extracts on metabolic syndrome.
- To explore potential synergistic effects and therapeutic applications.
- To assess the impact on cardiovascular risk factors.
Main Methods:
- Systematic search of randomized clinical trials (RCTs) across four databases.
- Meta-analysis and qualitative analysis of eligible studies.
- Included seven RCTs with 332 participants.
Main Results:
- HS combined with plant extracts significantly improved anthropometric parameters.
- Blood pressure and lipid profiles (LDL cholesterol, total cholesterol) were positively affected.
- Compared to placebo, HS demonstrated beneficial cardiovascular effects.
Conclusions:
- HS in combination with other plant extracts may offer benefits for cardiovascular health in metabolic syndrome.
- Further research is required to establish optimal dosage and duration.
- Synergistic effects of HS and plant extracts warrant continued investigation.
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