Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flavio Pisani1, Valerio Pisani2, Francesca Arcangeli3

  • 1Faculty of Clinical and Biomedical Sciences, School of Dentistry, University of Central Lancashire, Preston PR1 2HE, UK.

International Journal of Environmental Research and Public Health
|June 10, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic-Assisted Rehabilitation and Spinal Neuromodulation After Spinal Cord Injury: From Mechanisms to Trial-Informed Practice.

Journal of clinical medicine·2026
Same author

Editorial: Genetic and environmental interactions in oral disease: advancing diagnostic and therapeutic strategies.

Frontiers in medicine·2025
Same author

Comparison of Clinical Outcomes of Two Hydraulic Calcium Silicate Cements for Pulpotomy in Cariously Exposed Permanent Teeth-A Systematic Review.

Australian endodontic journal : the journal of the Australian Society of Endodontology Inc·2025
Same author

Influence of scanning plane on Human Spinal Cord functional Magnetic Resonance echo planar imaging.

PloS one·2025
Same author

Assessing medical students' awareness of the link between oral and systemic health: a questionnaire-based study in a cohort of year 3 and 4 MBBS students in the UK.

Minerva dental and oral science·2025
Same author

The Role of Psychological Variables in Predicting Rehabilitation Outcomes After Spinal Cord Injury: An Artificial Neural Networks Study.

Journal of clinical medicine·2024

This review explores the hypothesis that the bacterium Treponema denticola may initiate Alzheimer's disease (AD) pathology by damaging peripheral nerves and evading immune responses, potentially leading to neurodegeneration.

Area of Science:

  • Neuroscience
  • Microbiology
  • Pathology

Background:

  • Alzheimer's disease (AD) is a leading cause of dementia, characterized by amyloid-beta plaques and tau tangles.
  • Traditional AD progression models focus on cortical spread, but emerging evidence suggests a potential midbrain origin.
  • Spirochetes are known to be neurotrophic, capable of reaching the brain via the midbrain.

Purpose of the Study:

  • To review the hypothesis that Treponema denticola contributes to Alzheimer's disease pathogenesis.
  • To explore the mechanisms by which T. denticola might cause axonal damage, immune evasion, and neuronal apoptosis.
  • To propose a pathogenetic model for advanced AD involving T. denticola.

Main Methods:

  • Review of existing literature on T. denticola, neurodegeneration, and immune responses.
Keywords:
Alzheimer’s diseaseTreponema denticolaaxonal transportcytoskeletal impairmentmitochondrial dockingneurodegenerationperiodontal diseaseperipheral nerve

Related Experiment Videos

  • Analysis of spirochete virulence factors and their interaction with host cells like microglia.
  • Discussion of biofilm formation and quorum sensing in T. denticola's immune resistance.

    • Main Results:

    • T. denticola may damage peripheral axons and evade immune responses, including complement and microglial activity.
    • Bacterial virulence factors can lead to cytoskeletal impairment, disrupted axonal transport, and altered mitochondrial function.
    • These disruptions can result in neuronal apoptosis, potentially contributing to AD progression.

    Conclusions:

    • Treponema denticola is proposed as a potential etiological agent in Alzheimer's disease, particularly in advanced stages.
    • The bacterium's ability to damage peripheral nerves and evade immunity offers a novel perspective on AD pathogenesis.
    • Further research into T. denticola's role, especially its biofilm and quorum sensing mechanisms, is warranted to understand its central neurodegeneration pathways.