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Behçet's Disease Uveitis.

Morgane Joubert1, Anne-Claire Desbois1, Fanny Domont1

  • 1AP-HP. Centre de Référence des Maladies Auto-Immunes Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires et de l'Amylose Inflammatoire, F-75013 Paris, France.

Journal of Clinical Medicine
|June 10, 2023
PubMed
Summary
This summary is machine-generated.

Behçet

Keywords:
Behçet’s diseaseanti TNF-α agentsbiotherapiesuveitisvasculitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Behçet's disease (BD) frequently causes uveitis, a significant cause of morbidity, affecting 40% of patients.
  • Ocular involvement, including anterior, posterior, or panuveitis, often appears in early adulthood (20-30 years) and can be an initial disease manifestation.
  • Panuveitis is the most common presentation, particularly in men, with bilateralization occurring approximately two years after symptom onset, carrying a 10-15% risk of blindness within five years.

Purpose of the Study:

  • To provide an updated review on the pathogenesis, diagnostic approaches, and therapeutic strategies for uveitis in Behçet's disease.
  • To highlight the distinct ophthalmological features of BD uveitis compared to other uveitic conditions.
  • To emphasize the goals of managing BD uveitis: rapid inflammation resolution, prevention of recurrence, achieving remission, and preserving vision.

Main Methods:

  • Literature review focusing on pathogenesis, diagnosis, and treatment of Behçet's disease uveitis.
  • Analysis of clinical features and epidemiological data related to ocular involvement in BD.
  • Evaluation of the impact of biologic therapies on managing intraocular inflammation in BD uveitis.

Main Results:

  • Behçet's disease uveitis presents with diverse ocular manifestations and distinct features.
  • Biologic therapies have significantly advanced the management of intraocular inflammation in BD uveitis.
  • Effective management strategies aim for rapid inflammation control, recurrence prevention, and vision preservation.

Conclusions:

  • Uveitis is a major complication of Behçet's disease requiring specialized management.
  • Early diagnosis and prompt, aggressive treatment, including biologics, are crucial for favorable visual outcomes.
  • Ongoing research into pathogenesis and novel therapeutics continues to improve patient care for BD uveitis.