Related Experiment Video
Updated: Jul 27, 2025
Author Spotlight: Neuromotor Control and Recovery of Diaphragm Function Following Cervical Spinal Hemisection in Rats
Published on: June 14, 2024
Smoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Study
Ricardo Aparecido Baptista Nucci1,2, Alexandre Leopold Busse1,2, Romeu Rodrigues de Souza3,4
1Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Background:
Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples.
Methods:
Subjects were divided into three groups: never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure.
Results:
Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations.
Conclusions:
Pack-years of smoking was associated with DIAm injury. However, further clinicopathological studies are needed to confirm our findings.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:20Chronic Obstructive Pulmonary Disease-I: Introduction