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Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected

Sosuke Fukui1,2, Masashi Mizuno1,2, Mitsuhiro Tawada1

  • 1Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

International Journal of Molecular Sciences
|June 10, 2023
PubMed

Insights

Peritoneal dialysis patients with fungal or Pseudomonas aeruginosa peritonitis experience severe peritoneal injuries. These injuries reduce protective complement regulators, increasing susceptibility to further damage.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Fungal and Pseudomonas aeruginosa infections are linked to poor outcomes in peritoneal dialysis (PD) peritonitis.
  • Complement regulators (CRegs) protect tissues, but their role in PD peritonitis is unclear.

Purpose of the Study:

  • To investigate peritoneal tissue injuries and CReg expression (CD46, CD55, CD59) in PD patients with peritonitis.
  • To compare injuries and CRegs between fungal/Pseudomonas aeruginosa peritonitis (P1) and Gram-positive bacterial peritonitis (P2).

Main Methods:

  • Analysis of peritoneal biopsy tissues from PD patients undergoing catheter removal.
  • Assessment of peritonitis severity, CReg expression, and complement activation products (C3, C5b-9).
  • Comparison between patients with no peritonitis, P1, and P2.

Main Results:

  • Peritoneal injuries correlated inversely with CReg expression; peritonitis reduced CRegs compared to controls.
  • Peritoneal injuries were more severe in P1 than P2.
  • P1 showed lower CReg expression and higher C5b-9 levels than P2.

Conclusions:

  • Severe peritoneal injuries in fungal and Pseudomonas aeruginosa peritonitis are associated with decreased CReg expression.
  • Reduced CRegs and increased complement activation (C3, C5b-9) may heighten susceptibility to further peritoneal damage in these patients.
Keywords:
PD-related peritonitiscomplementfungal infectionmembrane complement regulatorperitoneal dialysis

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