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Updated: Jul 27, 2025
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
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Nuclear Receptors in Health and Diseases
Pengfei Xu1,2
1Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
International Journal of Molecular Sciences
|June 10, 2023
Summary
Nuclear receptors (NRs) are key transcription factors regulating bodily functions and drug responses. Understanding NRs is vital for developing new therapeutic strategies and advancing pharmacological research.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Nuclear receptors (NRs) are a crucial superfamily of transcription factors.
- NRs regulate diverse physiological processes, including metabolism, development, and reproduction.
- Dysregulation of NRs is implicated in various diseases, highlighting their pharmacological importance.
Discussion:
- NRs serve as critical targets for drug development.
- The structure and function of NRs are extensively studied to understand their roles in health and disease.
- Pharmacological modulation of NRs offers therapeutic potential for metabolic disorders, cancer, and inflammatory conditions.
Key Insights:
- NRs integrate signals from ligands to control gene expression.
- Specific NR subtypes exhibit distinct tissue expression patterns and functions.
- Targeting NRs can influence complex biological pathways relevant to human health.
Outlook:
- Further research into NR signaling pathways will uncover novel therapeutic targets.
- Developing selective NR modulators is a key goal for precision medicine.
- NRs represent a promising area for future drug discovery and development.
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