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Protein Posttranslational Modification in Stemness Remodeling and Its Emerging Role as a Novel Therapeutic Target in

Yifei Wang1, Man Tong1

  • 1School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

International Journal of Molecular Sciences
|June 10, 2023
PubMed

Insights

Posttranslational modifications (PTMs) regulate protein function and are crucial in cancer. This review explores how PTMs reprogram gastrointestinal cancer stemness, offering new therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • Posttranslational modifications (PTMs) are vital protein regulatory mechanisms.
  • PTMs influence proteome diversity and complex biological processes.
  • PTMs are increasingly recognized for their role in cancer development, recurrence, and therapy resistance.

Purpose of the Study:

  • To review the latest findings on protein PTMs in reprogramming gastrointestinal (GI) cancer stemness.
  • To elucidate the mechanisms by which PTMs maintain cancer stemness and drive therapeutic resistance.
  • To highlight the clinical relevance of PTMs as biomarkers and therapeutic targets in GI malignancies.

Main Methods:

  • Literature review focusing on recent advancements in PTMs and cancer stemness.
  • Analysis of PTM profiles in various tumor types, particularly GI cancers.
  • Examination of signaling pathways involved in PTM-mediated stemness regulation.

Main Results:

  • PTMs play a significant role in modulating cancer stemness across different tumor types.
  • Aberrant PTMs are implicated in neoplastic transformation, tumor recurrence, and resistance to oncotherapy.
  • Specific PTMs are identified as key regulators of gastrointestinal cancer stem cell self-renewal and differentiation.

Conclusions:

  • Understanding abnormal PTMs in GI cancer offers opportunities to target cancer stem cells.
  • PTMs represent promising biomarkers for GI cancer diagnosis and prognosis.
  • Targeting PTMs presents a novel therapeutic strategy for GI malignancies.
Keywords:
cancer stem cellsgastrointestinal cancersposttranslational modificationstemness

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