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Lunasin and Its Epigenetic Impact in Cancer Chemoprevention

Agnieszka Kaufman-Szymczyk1, Wiktoria Kaczmarek1, Krystyna Fabianowska-Majewska2

  • 1Department of Biomedical Chemistry, Faculty of Health Sciences, Medical University of Lodz, 92-215 Lodz, Poland.

International Journal of Molecular Sciences
|June 10, 2023
PubMed

Insights

Lunasin, a soy peptide, shows promise as an anti-cancer agent by modulating epigenetic factors. This review explores its mechanisms for cancer prevention and therapy.

Area of Science:

  • Oncology
  • Nutritional Science
  • Epigenetics

Background:

  • Cancer is a leading global cause of mortality, necessitating research into preventative dietary compounds.
  • Legumes and vegetables contain chemopreventive substances with potential anti-cancer properties.
  • Lunasin, a peptide from soy, has been investigated for over two decades for its anti-cancer effects.

Purpose of the Study:

  • To review the molecular mechanisms of lunasin's anti-cancer activity.
  • To discuss new perspectives on lunasin's application in epigenetic cancer prevention and therapy.

Main Methods:

  • Review of existing scientific literature on lunasin.
  • Analysis of studies on molecular mechanisms including histone acetylation, cell cycle regulation, proliferation, and apoptosis.

Main Results:

  • Lunasin inhibits histone acetylation, a key epigenetic modification.
  • It regulates the cell cycle, suppresses cancer cell proliferation, and induces apoptosis.
  • Lunasin acts as a potent epigenetic modulator with significant anti-cancer potential.

Conclusions:

  • Lunasin is a promising bioactive compound for cancer prevention and therapy.
  • Its epigenetic modulating properties offer novel therapeutic strategies.
  • Further research into lunasin's application in oncology is warranted.
Keywords:
DNA methylationchemopreventionepigenetic anti-cancer therapyepinutrienthistone acetylationlunasin

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