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Targeting IGF2BP3 in Cancer.

Xin Liu1, Jiayu Chen1, Wenliang Chen1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.

International Journal of Molecular Sciences
|June 10, 2023
PubMed
Summary

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is crucial in RNA modification and cancer. This study reviews its biological roles and tumor mechanisms, highlighting IGF2BP3 as a potential therapeutic target.

Keywords:
IGF2BP3cancer-promoting factorm6A binding proteinradiosensitivitytumor immunity

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • RNA-binding proteins (RBPs) regulate gene expression through RNA interactions.
  • N6-methyladenosine (m6A) is the most prevalent RNA modification in eukaryotes.
  • Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is implicated in m6A modification and cellular functions.

Purpose of the Study:

  • To summarize the physiological functions of IGF2BP3.
  • To elucidate the role and molecular mechanisms of IGF2BP3 in tumorigenesis.
  • To evaluate IGF2BP3 as a potential therapeutic target and prognostic marker in cancer.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of IGF2BP3 expression patterns in various cancers.
  • Investigation of IGF2BP3's involvement in m6A-dependent pathways.

Main Results:

  • IGF2BP3 is frequently overexpressed in human cancers.
  • Abnormal IGF2BP3 expression correlates with poor patient prognosis.
  • IGF2BP3 plays significant roles in RNA stability, localization, and immunity, impacting cancer progression.

Conclusions:

  • IGF2BP3 is a key player in m6A RNA modification and cancer development.
  • Targeting IGF2BP3 may offer a novel therapeutic strategy for cancer treatment.
  • IGF2BP3 serves as a promising prognostic biomarker for various malignancies.