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Related Concept Videos

Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

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The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
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Physiology of Enteric Nervous System and Gut Health01:05

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Nerve Supply of the GI Tract01:27

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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Autonomic Nervous System: Overview01:26

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The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
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Related Experiment Video

Updated: Jul 27, 2025

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
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The Aging Enteric Nervous System.

Tinh Thi Nguyen1,2, Peter Baumann3, Oliver Tüscher1,4,5

  • 1Department of Psychiatry and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany.

International Journal of Molecular Sciences
|June 10, 2023
PubMed
Summary
This summary is machine-generated.

Aging alters the gut's nervous system (enteric nervous system), impacting gut function and potentially contributing to brain diseases like Alzheimer's and Parkinson's.

Keywords:
agingenteric nervous systemgutgut–brain axismicrobiotaneurodegenerative disease

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Aging Research

Background:

  • The gut-brain axis describes bidirectional communication between the gastrointestinal tract and the central nervous system.
  • The gut is exposed to external factors, making its aging process distinct from the brain's.
  • Age-related gut dysfunction is linked to neurodegenerative diseases.

Purpose of the Study:

  • To review how normal cellular aging affects the physiological changes in the enteric nervous system (ENS).
  • To explore the ENS's role in age-associated gastrointestinal dysfunction and neurodegeneration.

Main Methods:

  • Review of existing literature on aging of the ENS.
  • Analysis of morphological and functional changes in the aging ENS from animal models and human studies.

Main Results:

  • The aging ENS exhibits morphological alterations and degeneration, though with variability.
  • Aging of the ENS is implicated in age-related central nervous system diseases, including Alzheimer's and Parkinson's.

Conclusions:

  • Cellular aging significantly impacts the ENS, leading to functional changes.
  • The ENS is a potential diagnostic and therapeutic target for age-related neurodegenerative diseases due to its accessibility.