Advances in Bcl-xL Research 2.0

Related Experiment Video

Updated: Jul 27, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

7.9K

Joann Kervadec1, Muriel Priault1

  • 1Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.

International Journal of Molecular Sciences
|June 10, 2023
PubMed

Abstract:

Apoptosis is a form of programmed cell death that is highly conserved in metazoan organisms, where it ensures the proper development and homeostasis of tissues [...].

More Related Videos

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

2.6K
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.0K

Related Experiment Videos

Last Updated: Jul 27, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

7.9K
Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

2.6K
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.0K

Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K

Articles linked to this work by shared authors, journal, and citation graph.

Mechanism-Driven Features Enable Asn Deamidation Reactivity Prediction via Machine Learning Methods.

Journal of chemical information and modeling·2025

The membrane insertion of the pro-apoptotic protein Bax is a Tom22-dependent multi-step process: a study in nanodiscs.

Cell death discovery·2024

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System.

Biomolecules·2023

Inhibition of Autophagy Negates Radiofrequency-Induced Adaptive Response in SH-SY5Y Neuroblastoma Cells.

International journal of molecular sciences·2022

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.

Biomolecules·2022

Label-Free Study of the Global Cell Behavior during Exposure to Environmental Radiofrequency Fields in the Presence or Absence of Pro-Apoptotic or Pro-Autophagic Treatments.

International journal of molecular sciences·2022

Revisiting the universality of direct pectoral fin development in catfishes: Evidence from the Asian red-tail catfish Hemibagrus wyckioides.

Developmental dynamics : an official publication of the American Association of Anatomists·2026

[Analysis of Genetic Characteristics of Mitochondrial DNA Genetic Variation in Four⁃Generation Maternal Lineages].

Fa yi xue za zhi·2026

Modelling the movements of organisms by stochastic theory in a comoving frame.

Movement ecology·2026

ESM-embedR: a protein language model framework for comparative mutation analysis and computational atypicality scoring of Lassa and Ebola virus sequences.

BMC bioinformatics·2026

Reduced hypoxanthine Ameliorates LPS-triggered autism-like stereotyped behaviors in intestinal Tlr4 knockout mice via the DRN ROS-5-HT axis.

Biochemical pharmacology·2026

Long-Term Disease Stability and Radiological Progression in Low-Grade Glioma: A Retrospective MRI-Based Cohort Study of Post-surgical and Observation Groups.

Cureus·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us