Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles

Area of Science:

• Pharmaceutical Sciences
• Nanotechnology
• Drug Delivery Systems

Background:

• Nasal drug delivery offers advantages like direct central nervous system (CNS) access and improved patient compliance.
• Current nasal formulations are predominantly liquids, limiting precise administration and potentially affecting bioavailability.
• Developing solid-state nasal delivery systems can overcome limitations of liquid formulations.

Purpose of the Study:

• To develop an innovative solid-state nanosystem for nasal drug delivery.
• To enhance the bioavailability of chlorpromazine (CPZ) via nasal administration.
• To create a targeted delivery system for direct CNS drug delivery.

Main Methods:

• Formulation of solid nanosystems incorporating chlorpromazine (CPZ) using amphiphilic compounds with adhesive and penetration-enhancing properties.
• Utilized Büchi B90 nanospray dryer for nanoparticle formation and characterized nanostructures via particle size analysis.
• Assessed biocompatibility and studied CPZ bioavailability through nasal and intravenous administration comparisons; developed a 3D-printed nasal dosing device.

Main Results:

• Successfully constructed solid drug delivery nanosystems with desirable adhesive and penetration-enhancing properties.
• Demonstrated safe applicability of the developed systems through various biocompatibility assays.
• The study provides a foundation for designing and scaling up high-bioavailability nasal medicinal products.

Conclusions:

• The developed solid nanosystem offers a promising alternative to liquid nasal formulations, enhancing drug bioavailability and enabling direct CNS targeting.
• The incorporation of specific excipients and the use of nanospray drying technology were crucial for system development.
• The novel 3D-printed nasal dosing device facilitates accurate administration of the solid nanosystem, paving the way for advanced nasal therapeutics.