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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Related Experiment Video

Updated: Jul 27, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Chronic Inflammation's Transformation to Cancer: A Nanotherapeutic Paradigm.

Sayed Sartaj Sohrab1,2, Riya Raj3, Amka Nagar4

  • 1Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Molecules (Basel, Switzerland)
|June 10, 2023
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Summary
This summary is machine-generated.

Chronic inflammation drives diseases like cancer through specific pathways. Nanotechnology offers a promising approach to reduce inflammation and oxidative stress, aiding in the treatment of these challenging conditions.

Keywords:
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Area of Science:

  • Biomedical Science
  • Oncology
  • Immunology

Background:

  • Inflammation is a normal immune response that can lead to chronic inflammatory diseases, including cancer.
  • Chronic inflammation promotes cancer progression through complex interactions within the tumor microenvironment.
  • Existing treatments for chronic inflammatory diseases are challenging, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the inflammatory pathways linking inflammation to cancer.
  • To discuss major inflammatory diseases and their mechanisms.
  • To explore the potential of nanotechnology in managing chronic inflammation-related diseases.

Main Methods:

  • Literature review of inflammatory pathways and cancer development.
  • Analysis of molecular mechanisms connecting inflammation and tumorigenesis.
  • Examination of nanoparticle properties and applications in disease treatment.

Main Results:

  • Identified extrinsic and intrinsic pathways linking inflammation and cancer, involving key transcription factors and mediators.
  • Highlighted the role of cytokines, chemokines, and cellular components in promoting tumorigenesis.
  • Demonstrated the potential of nanoparticles in reducing inflammation and oxidative stress.

Conclusions:

  • Understanding the molecular links between inflammation and cancer is crucial for developing effective therapies.
  • Nanotechnology presents a promising avenue for innovative treatments targeting chronic inflammation and associated diseases like cancer.
  • Early detection and diagnosis remain critical for managing these complex conditions.