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Updated: Jul 27, 2025

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Published on: May 29, 2021
XDH and XO Research and Drug Discovery-Personal History
1NESA LLC, Yamatomura Greenhouse 501, Honkomagome 6-13-6, Bunkyo-ku, Tokyo 113-0021, Japan.
Abstract:
The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of this conversion was elucidated in this study. The physiological and pathological significance of this conversion is presented. Finally, enzyme inhibitors were successfully developed, two of which are used as therapeutic agents for gout. Their wide application potential is also discussed.
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