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Cardioprotective Properties of Kaempferol: A Review

Yusof Kamisah1, Juriyati Jalil2, Nurhanan Murni Yunos3

  • 1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Plants (Basel, Switzerland)
|June 10, 2023
PubMed

Insights

Kaempferol, a plant flavonoid, shows promise in protecting the heart from damage. This review details its antioxidant and anti-inflammatory effects, improving cardiac function in various injury models.

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Natural Products

Background:

  • Cardiac diseases like myocardial infarction and heart failure pose significant global health challenges.
  • Bioactive compounds with antioxidant and anti-inflammatory properties are increasingly recognized for their cardioprotective potential.

Purpose of the Study:

  • To review and synthesize current research on the cardioprotective effects of kaempferol.
  • To explore kaempferol's impact on various cardiac injury models and its underlying mechanisms.

Main Methods:

  • Literature review of studies investigating kaempferol's effects on cardiac injury.
  • Analysis of experimental data from various cardiac injury models.
  • Synthesis of findings related to kaempferol's biochemical and cellular actions.

Main Results:

  • Kaempferol demonstrates significant cardioprotective effects across multiple cardiac injury models.
  • It alleviates myocardial apoptosis, fibrosis, oxidative stress, and inflammation.
  • Kaempferol preserves mitochondrial function and calcium homeostasis in the heart.

Conclusions:

  • Kaempferol exhibits broad cardioprotective properties, making it a potential therapeutic agent for cardiac diseases.
  • Further research is needed to fully elucidate the mechanisms of action for kaempferol's cardioprotective effects.
  • Understanding these mechanisms could guide future therapeutic strategies for heart conditions.

Keywords:
anti-inflammatoryantiapoptosisantifibrosisantioxidantcalcium regulationcardiac diseasecardiac functionflavonoid

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