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Related Concept Videos

Production of Organic Acids01:25

Production of Organic Acids

Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...

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Construction and Characterization of a Novel Vocal Fold Bioreactor
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Novel Rhinological Application of Polylactic Acid-An In Vitro Study.

M P Gowrav1, K G Siree1, T M Amulya2

  • 1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India.

Polymers
|June 10, 2023
PubMed
Summary

This study introduces a novel 3D-printed nasal stent loaded with corticosteroids to treat sinusitis. The customized polylactic acid stent prevents sinus closure and ensures consistent drug delivery for improved wound healing.

Keywords:
3D printed nasal stentsbiomaterialsbiomaterials in 3D printingendoscopic sinus surgerynasal stentssinusitis

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Area of Science:

  • Biomaterials Engineering
  • Drug Delivery Systems
  • Otolaryngology

Background:

  • Sinusitis treatment often faces challenges with wound healing and re-occlusion.
  • Nasal stents can maintain sinus patency but require effective drug delivery.
  • Customization and controlled drug release are key for advanced stent therapies.

Purpose of the Study:

  • To develop and characterize a novel 3D-printed nasal stent for sinusitis treatment.
  • To incorporate corticosteroids into a polylactic acid stent for enhanced wound healing.
  • To evaluate drug loading, release kinetics, and mechanical properties of the novel stent.

Main Methods:

  • 3D printing of polylactic acid (PLA) nasal stents using fused deposition modeling.
  • Corticosteroid loading via solvent casting method.
  • Characterization using FT-IR, DSC, SEM, dissolution studies, and biodegradation tests.

Main Results:

  • Successful fabrication of customizable 3D-printed PLA nasal stents.
  • Achieved significant drug loading (68% on filaments, 72.8% on stent).
  • Demonstrated consistent drug release profiles and acceptable mechanical properties for nasal application.

Conclusions:

  • The developed 3D-printed nasal stent effectively incorporates and releases corticosteroids.
  • This novel stent offers a promising solution for preventing sinus re-closure and improving sinusitis treatment outcomes.
  • The customized, drug-eluting stent design enhances therapeutic potential in otolaryngology.