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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Monitoring Spatial Segregation in Surface Colonizing Microbial Populations
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Signaling in microbial communities with open boundaries.

James J Winkle1, Soutick Saha2, Joseph Essman3

  • 1Department of Mathematics, University of Houston, Houston, Texas.

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|June 10, 2023
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Summary
This summary is machine-generated.

Mathematical modeling reveals how boundary flows and microbial community geometry impact cell-cell signaling. Signaling lengthscale can depend on geometry alone, challenging traditional diffusion-based assumptions.

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Area of Science:

  • Microbiology
  • Mathematical Biology
  • Systems Biology

Background:

  • Microbial communities form at interfaces of solid substrates and fluid flows.
  • Microfluidic devices are common for studying these communities, presenting open-boundary conditions.
  • Extracellular signaling in open systems is less understood than in closed systems.

Purpose of the Study:

  • To investigate the impact of advective-diffusive boundary flows and population geometry on cell-cell signaling in microbial monolayers.
  • To reveal conditions where signaling lengthscale is independent of diffusion and degradation.

Main Methods:

  • Utilized mathematical modeling to simulate signaling dynamics.
  • Analyzed the interplay between boundary flow, population geometry, and intercellular communication.

Main Results:

  • Identified conditions where intercellular signaling lengthscale is determined solely by population geometry.
  • Demonstrated that diffusive coupling with boundary flow can induce signal gradients within isogenic populations, even without internal flow.
  • Provided new theoretical insights into published experimental findings.

Conclusions:

  • Boundary dynamics and environmental geometry are crucial factors in modeling microbial cell-cell signaling.
  • The study offers experimentally verifiable predictions for future research.
  • Informs the understanding of cell behavior in natural and synthetic microbial systems.