Relationship Between the Coma Scores and Hemogram Parameters Measured by New-generation Devices.

Area of Science:

• Critical Care Medicine
• Hematology
• Clinical Pathology

Background:

• Coma scores (Glasgow Coma Scale - GCS, Sequential Organ Failure Assessment - SOFA, Acute Physiological and Chronic Health Assessment - APACHE-II) are crucial for assessing patient severity in Intensive Care Units (ICUs).
• Hematological parameters can offer insights into patient prognosis and underlying physiological status.

Purpose of the Study:

• To investigate the association between various coma scores (GCS, SOFA, APACHE-II) and specific hematological parameters in ICU patients.
• To evaluate the potential of novel hematological markers as prognostic indicators in critical care.

Main Methods:

• A descriptive comparative study was conducted with ICU patients and a healthy control group.
• Hemogram parameters were analyzed using the AlinityHQ autoanalyzer and compared with GCS, SOFA, and APACHE-II scores.

Main Results:

• Statistically significant differences were found in Immature Granulocyte (IG), % Macrocytosis (%MAC), and Platelet Distribution Width (PDW) values, showing inverse correlations with GCS scores.
• Significant correlations were also observed between SOFA scores and % Hyperchromic Ratio (%HPR)/Cellular Hemoglobin Concentration (cHGB), and APACHE-II scores and Nucleated Red Blood Cell (NRBC)/Nucleated Red Cell/White Cell Ratio (NR/W).

Conclusions:

• Hematological parameters such as %MAC, IG, cHGB, NRBC, NR/W, and %HPR, measured by new-generation devices, are associated with coma scores.
• These parameters show potential as simple, rapid prognostic biomarkers in ICU settings.
• The findings may contribute to the development of new scoring models for critical care patients.