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Updated: Jul 27, 2025

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YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division

Mankun Wei1,2, Uli Nurjanah1,2, Juan Li1,2

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 10, 2023
PubMed
Summary

Yin Yang 2 (YY2) suppresses liver cancer stem cell (CSC) division by regulating mitochondrial fission. Lower YY2 levels correlate with poor prognosis, suggesting YY2 as a therapeutic target to deplete CSCs.

Keywords:
CSC asymmetric divisioncancer stem cells (CSCs)dynamin-related protein 1 (DRP1)mitochondria fissionyin yang 2 (YY2)

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