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Published on: November 29, 2019
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Serum biomarkers in normal pressure hydrocephalus
Enra Mehmedika-Suljić1,2, Sebija Izetbegović2,3, Nafija Serdarević4,5
1Department of Neurology, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Summary
Serum levels of brain-derived neurotrophic factor (BDNF) and other biomarkers showed no significant differences in normal pressure hydrocephalus (NPH) patients compared to controls. A correlation was found between BDNF and the Evans index in NPH patients.
Area of Science:
- Neurology
- Biochemistry
- Neuroscience
Background:
- Normal pressure hydrocephalus (NPH) is a neurological condition characterized by gait disturbance, urinary incontinence, and cognitive impairment.
- Biomarkers such as brain-derived neurotrophic factor (BDNF), S-100, NSE, and IL-6 are implicated in various neurological disorders.
- Understanding the role of these biomarkers in NPH may provide insights into disease mechanisms and potential diagnostic tools.
Purpose of the Study:
- To compare serum concentrations of BDNF, S-100, NSE, and IL-6 in patients with NPH versus a healthy control group.
- To investigate potential correlations between these serum biomarkers and radiological findings, specifically the Evans index, in NPH patients.
Main Methods:
- Serum samples were collected from seven NPH patients and eight healthy controls between 2020 and 2022.
- BDNF levels were measured using ELISA, while S-100, NSE, and IL-6 were quantified using ECLIA.
- Correlation analysis was performed between biomarker levels and the Evans index in NPH patients.
Main Results:
- No statistically significant differences were observed in serum concentrations of BDNF, S-100, NSE, or IL-6 between NPH patients and controls.
- A strong positive correlation was found between serum BDNF levels and the Evans index in NPH patients (p=0.0295).
- Trends suggested a decrease in BDNF and NSE, and an increase in S-100 and IL-6 in NPH patients, though not statistically significant.
Conclusions:
- This study did not find significant differences in serum BDNF, S-100, IL-6, and NSE levels between NPH patients and healthy individuals.
- The observed correlation between BDNF and the Evans index warrants further investigation.
- Additional research is necessary to elucidate the precise role of BDNF and other biomarkers in the pathophysiology of NPH.
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