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Related Experiment Video

Updated: Jul 27, 2025

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Rapid On-Site Evaluation (ROSE): A Microfluidic Approach.

Filipe Marques1, Janosch Hauser1, Niclas Roxhed2

  • 1Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.

Methods in Molecular Biology (Clifton, N.J.)
|June 10, 2023
PubMed
Summary

A new semiautomated device simplifies sample preparation for rapid on-site evaluation (ROSE) of fine-needle aspiration (FNA) samples. This innovation aims to improve diagnostic accuracy and broaden the use of ROSE in clinical settings.

Keywords:
Capillary microfluidicsCystic fluidCytologyFine-needle aspirationPoint-of-careRapid on-site evaluation

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Area of Science:

  • Biomedical Engineering
  • Medical Diagnostics
  • Microfluidics

Background:

  • Rapid on-site evaluation (ROSE) enhances diagnostic accuracy for fine-needle aspiration (FNA) biopsies.
  • ROSE's effectiveness is limited by cytopathologist availability and required expertise.
  • Cysts, fluid-containing tissues, can be precancerous, necessitating accurate and timely diagnosis.

Purpose of the Study:

  • To develop and evaluate a semiautomated sample preparation device for ROSE.
  • To streamline the smearing and staining process for FNA samples.
  • To reduce equipment needs for ROSE in clinical settings.

Main Methods:

  • A semiautomated device integrating a smearing tool and capillary-driven chamber was designed.
  • The device performs smearing and staining of FNA samples on a single platform.
  • Device performance was tested using a human pancreatic cancer cell line (PANC-1) and FNA model samples (liver, lymph node, thyroid).

Main Results:

  • The device successfully prepared samples for ROSE.
  • Microfluidics enabled efficient sample processing.
  • The system demonstrated potential for simplified FNA sample preparation.

Conclusions:

  • The developed device offers a promising solution for semiautomated FNA sample preparation for ROSE.
  • This technology may increase the accessibility and implementation of ROSE in healthcare centers.
  • Reduced equipment requirements can facilitate wider adoption of ROSE, improving diagnostic capabilities.