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Updated: Jul 27, 2025

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

Published on: April 6, 2021

Portable microfluidic impedance biosensor for SARS-CoV-2 detection.

Soroush Laleh¹, Bergoi Ibarlucea², Marlena Stadtmüller³

¹Micro- and NanoBiomedical Engineering Group (MNBE), Institute for Emerging Electronic Technologies, Leibniz Institute for Solid State and Materials Research (Leibniz IFW Dresden), 01069, Dresden, Germany; Chair of Micro- and NanoSystems, Center for Molecular Bioengineering (B CUBE), Dresden University of Technology, 01062, Dresden, Germany.

Biosensors & Bioelectronics

|June 10, 2023

Summary

This summary is machine-generated.

This study presents a new microfluidic biosensor for rapid, portable detection of SARS-CoV-2, enabling early diagnosis of COVID-19. The device offers reliable results for patient samples, advancing point-of-care diagnostics.

Keywords:

COVID-19 diagnostics Electrochemical detection Electrochemical impedance spectroscopy Point-of-care SARS-CoV-2 biosensor

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Last Updated: Jul 27, 2025

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

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Area of Science:

Biomedical Engineering
Nanotechnology
Infectious Disease Diagnostics

Background:

Current pandemic threats necessitate rapid, accessible diagnostic tools.
Standard polymerase chain reaction (PCR) is accurate but slow, costly, and requires specialized facilities.
Need for miniaturized, portable sensors for early pathogen detection and disease monitoring.

Purpose of the Study:

Develop a sensitive microfluidic impedance biosensor for direct SARS-CoV-2 detection.
Create a mobile point-of-care (POC) platform for rapid diagnostics.
Enable early detection of pathogens and monitoring of viral load.

Main Methods:

Optimization of operational parameters using Design-of-Experiment (DoE).
Utilized electrochemical impedance spectroscopy (EIS) for viral antigen detection.
Validated biosensor performance with spiked buffer samples and real patient samples (Ct up to 27).

Main Results:

Achieved sensitive detection of SARS-CoV-2 at femtomolar (fM) concentration levels.
Demonstrated biosensor functionality with real patient samples.
Showcased platform versatility with portable potentiostats and smartphone-based readout.

Conclusions:

The developed microfluidic biosensor provides a rapid, reliable, and portable solution for COVID-19 diagnostics.
The platform's adaptability supports extension to other infectious diseases.
Facilitates monitoring of viral load in diverse populations for disease management.