Glypican1: A potential cancer biomarker for nanotargeted therapy
Abhay Dev Tripathi1, Soumya Katiyar1, Abha Mishra1
1School of Biochemical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.
Abstract:
Glypicans (GPCs) are generally involved in cellular signaling, growth and proliferation. Previous studies reported their roles in cancer proliferation. GPC1 is a co-receptor for a variety of growth-related ligands, thereby stimulating the tumor microenvironment by promoting angiogenesis and epithelial-mesenchymal transition (EMT). This work reviews GPC1-biomarker-assisted drug discovery by the application of nanostructured materials, creating nanotheragnostics for targeted delivery and application in liquid biopsies. The review includes details of GPC1 as a potential biomarker in cancer progression as well as a potential candidate for nano-mediated drug discovery.
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