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Synthesis and biological evaluation of biotinylated ZJ-101
Shan Qian1, Sarah A Head2, Phillip R Sanchez2
1Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Bioorganic & Medicinal Chemistry Letters
|June 10, 2023
Abstract:
ZJ-101 is a structurally simplified analog of marine natural product superstolide A that was previously designed and synthesized in our laboratory. Biological investigation shows that ZJ-101 maintains the potent anticancer activity of the original natural product with an undefined mechanism of action. To facilitate chemical biology study, a biotinylated ZJ-101 was synthesized and biologically evaluated.

