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Clinical investigation of the new dialyzer Gambro PRO-3
Abstract:
A new plate dialyzer, Gambro PRO-3, with a polycarbonate-polyether membrane (Gambrane) was tested. The membrane thickness is 16 micron and the dialyzer surface area 0.77 m2. 11 regular hemodialysis patients who were treated 3 times per week were studied and 32 dialyses were performed. Clearances of urea, creatinine, uric acid and inorganic phosphate at different blood flows were measured early and late in dialysis. Pulse rate and blood pressure were observed. Ultrafiltration rate and the residual blood volume were also measured. The performance of the dialyzer with regard to clearances was similar to that of the standard GLP 11.5 micron but inorganic phosphate clearance was slightly higher in PRO-3. The ultrafiltration of PRO-3 is about the same as for the GLP 11.5 micron dialyzer. No membrane leaks were observed, neither any adverse reactions in the patients.
Insights
The new Gambro PRO-3 dialyzer shows effective clearance of waste products like urea and creatinine, comparable to standard models. It demonstrated slightly higher inorganic phosphate clearance without adverse patient reactions during hemodialysis.
Area of Science:
- Nephrology
- Biomedical Engineering
- Materials Science
Background:
- Hemodialysis is a crucial treatment for end-stage renal disease.
- Dialyzer performance directly impacts patient outcomes.
- Evaluating new dialyzer technologies is essential for improving treatment efficacy.
Purpose of the Study:
- To assess the performance of the new Gambro PRO-3 plate dialyzer.
- To compare its clearance efficiency and ultrafiltration capabilities with a standard dialyzer.
- To evaluate patient safety and tolerance during hemodialysis.
Main Methods:
- Testing the Gambro PRO-3 dialyzer with a polycarbonate-polyether membrane (Gambrane).
- Studying 11 hemodialysis patients over 32 sessions, measuring clearances of urea, creatinine, uric acid, and inorganic phosphate.
- Monitoring vital signs, ultrafiltration rate, and residual blood volume.
Main Results:
- The PRO-3 dialyzer exhibited clearances similar to the standard GLP 11.5 micron dialyzer.
- A slightly higher clearance for inorganic phosphate was observed with the PRO-3.
- Ultrafiltration rates were comparable, and no membrane leaks or adverse patient reactions were reported.
Conclusions:
- The Gambro PRO-3 dialyzer is a safe and effective option for hemodialysis.
- Its performance is comparable to existing standards, with a potential advantage in phosphate removal.
- Further studies could explore long-term efficacy and patient benefits.