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Circulating Biomarkers in Coronary Microvascular Dysfunction

Teja Chakrala1, Roshni Prakash1, Carlos Valdes1

  • 1Department of Medicine University of Florida Gainesville FL USA.

Journal of the American Heart Association
|June 10, 2023
PubMed

Insights

Coronary microvascular dysfunction (CMD) is often missed but linked to poor outcomes. This review explores blood biomarkers for diagnosing and managing CMD by examining inflammation, oxidative stress, and endothelial dysfunction.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Pathophysiology

Background:

  • Coronary microvascular dysfunction (CMD) is an underdiagnosed condition.
  • CMD is associated with adverse clinical outcomes.
  • Current diagnostic methods for CMD can be limited.

Purpose of the Study:

  • To review current knowledge on circulating biomarkers for CMD.
  • To highlight biomarkers representing key pathophysiologic processes in CMD.
  • To inform clinicians on diagnostic and management strategies for CMD.

Main Methods:

  • Literature review of circulating biomarkers in CMD.
  • Analysis of biomarkers related to inflammation, endothelial dysfunction, oxidative stress, and coagulation.
  • Synthesis of findings to represent key pathophysiologic mechanisms.

Main Results:

  • Identified key circulating biomarkers associated with CMD.
  • Highlighted the role of inflammation and endothelial dysfunction markers.
  • Summarized biomarkers reflecting oxidative stress and coagulation pathways.

Conclusions:

  • Circulating biomarkers show promise for diagnosing and managing CMD.
  • Further research is needed to validate specific biomarkers for clinical use.
  • Biomarker panels may improve the understanding and treatment of CMD.

Keywords:
biomarkercirculating moleculescoronary microvascular dysfunction

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